Thursday, June 28, 2012

Bahrain releases leading activist, pays uprising victims

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

breaking dawn part 2 whitney cummings msnbc i will always love you maine caucus whitney houston has died blue ivy carter

Faster search, better photo sharing in new Android

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

bon vivant zynga ipo zynga ipo sam hurd arrested roddy white roddy white howard stern

Wednesday, June 27, 2012

The Essential Directions Of Exceptional Training Your Dog | Love ...

Studying training your dog are often very frustrating, but just like anything else, it is also quickly researched, trained, and used. Since you now have discovered this list of recommendations, with a little luck, you can be a little more knowledgeable in relation to proper dog training, to enable you to polish your techniques and also a effectively-behaved puppy.

Teach your pet the ?downward? control. This command is effective to construct on, or alone in unexpected emergency scenarios. Your dog that is aware his ?lower? command effectively can fall to the ground at the moment?s discover inside a testy circumstance, so that it is an excellent command to keep on hand for safety?s benefit.

So that you can workout a pet dog to get really well-mannered, you need to aim to make use of the words and phrases ?great? and ?no? as much as possible, which means your pet is aware of what these terms suggest. Simply by making these terms common terminology for the dog, you will have a better success rate of education your pet dog effectively. There is not any have to shout angrily on your pet, use a company strengthen when saying ?no?. On the other hand, use a hot enthusiastic color when you say ?very good?.

In case your pet is constantly inclined to burrow increase your backyard garden, it could be your fertilizer. Fertilizers made with manure or blood dish are exciting to dogs and entice these to the area. Try out changing your fertilizer using a plant-structured selection. Just be sure that whatever you choose continues to be safe to your canine.

A good way to your pet to discover innovative skills (or remember to brush through to some outdated versions) is always to enroll in classes at the community proper dog training center. Should you be unclear of where to acquire him, your friends or veterinary clinic may be able to support you in finding a location that matches your requirements.

See, it wasn?t that awful. As with any other issue, dog training is vast and it has a great deal of information available on it. At times you just need a little bit tip concerning where to start, to be able to start education your furry close friend. Hopefully, you may have acquired that details from all of these suggestions.

In my site in spanish como educar a un perro how to training a dog, share information about training puppy and dogs or in spanish adiestramiento canino for more information please clic in before link.

ryan howard ps i love you ray charles cheney heart transplant weather san diego unitarian new black panther party

Video: ?Magic Mike? star shows off his hot moves

Joan Rivers: I'm finally quitting Botox

There's never a dull moment when Joan Rivers visits. Hoda and Kathie Lee even joked about putting her on a delay Tuesday in case she should say something extra Joan Rivers-y. But she surprised everybody by keeping it clean, and announcing that she'd quit Botox.

john carter trans siberian orchestra trans siberian orchestra little big town little big town bennett bennett

Monday, June 25, 2012

Blazing Sun Run aims to help troops overseas

Don't worry if you did not hear the news about Paraguay impeaching its president.

After all, it happened so fast that even Paraguay's neighbors are figuring out how to react.

Paraguay, the small South American nation known as an "island surrounded by...

Read More ?

friday night lights nick santino bruce arians the misfits hook troy miracle

Wednesday, June 20, 2012

Africa and the Technology Revolution

frank martin pink slime

Europe hits Wall Street, Oracle rallies late

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

los angeles angels los angeles angels lindsay lohan̢۪s playboy cover leaked online lindsay lohan̢۪s playboy cover leaked online va tech shooting 2011 coriolanus coriolanus

Welker rambunctious as wedding approaches

???
Wes Welker's getting married in Aspen, Colorado on Saturday.

Apparently, he's not going down without a fight.

The New York Post reports that Welker and some friends tried to crash a party of excellent kids in Aspen and were summarily tackled by security.

According to the Post story, "when security tackled the group, witnesses said they still wouldn?t cooperate, and demanded to be let in right away."

That's resilience. And determination.

Welker's party reportedly got off with a good talking to.

football score ron paul nevada buffalo chicken dip super bowl 2012 soul train nevada caucus ufc 143

Monday, June 18, 2012

Romney won't say he'll overturn immigration order

TROY, Ohio (AP) ? Mitt Romney in an interview aired Sunday repeatedly refused to say that he would overturn President Barack Obama's new policy allowing some young illegal immigrants to stay in the United States. He claimed Obama's decision was political, while senior White House adviser David Plouffe said the move wasn't motivated by politics.

The Republican presidential candidate was asked several times in an interview on CBS' "Face the Nation" whether he would overturn the executive order issued Friday if he's elected in the fall. He refused to directly answer.

"It would be overtaken by events," Romney said when pressed for the second time by moderator Bob Schieffer during the interview taped Saturday while the former Massachusetts governor's bus tour stopped in Pennsylvania.

He explained the order would become irrelevant "by virtue of my putting in place a long-term solution, with legislation which creates law that relates to these individuals such that they know what their setting is going to be, not just for the term of a president but on a permanent basis."

Romney's Rust Belt tour swept through Ohio on Sunday, where he appeared with House Speaker John Boehner in the speaker's home district in Troy. Protesters shouted throughout his abbreviated campaign speech there, yelling "Romney go home!" as Romney campaign staff moved speakers into the group of protesters in attempt to drown them out in return.

The protest came just a few minutes after top Obama adviser David Axelrod posted a tweet saying he's opposed to efforts to shout down Romney's bus tour. Obama's Chicago campaign has been helping distribute information about protest events ? former Democratic Gov. Ed Rendell held a protest outside a Wawa on Saturday that prompted Romney to shift his tour to a different Wawa store than originally planned.

"I strongly condemn heckling along Mitt's route," Axelrod tweeted. "Let voters hear BOTH candidates and decide."

After the protests, though, Romney's event Sunday ended on a high note ? he climbed into the front seat of a 1961 Rambler, the car that helped his father turn around American Motors. George Romney's picture was in the old brochure still with the car. Romney sat in the front seat with the 20-year-old owner, Michael Scheib, who leaned over to tell Romney to "scare 'em, press them horn."

Romney honked, and the surprised crowd laughed.

Earlier in the day, Romney attended a Father's Day pancake breakfast with two of his sons and five of his 18 grandchildren. He told a rain-soaked crowd that the weather was a metaphor for the country and that "three and half years of dark clouds are about to part." At a second event in Newark, near Columbus, Romney told a cheering crowd that the president's slogan had changed.

"Last time when he was running for president his campaign theme was hope and change. This time he's hoping to change the subject because the American people are not happy," said Romney, speaking for about nine minutes as Occupy Wall Street protesters yelled from a nearby sidewalk.

In the TV interview, Romney suggested that Obama's decision on immigration was motivated by politics. "If he felt seriously about this he should have taken action when he had a Democrat House and Senate, but he didn't. He saves these sort of things until four and a half months before the general election," he said.

Plouffe, the Obama adviser, sent by the White House to four of the talk shows, contended that Obama's action, which appeals to Hispanic voters who are critical to the president's re-election effort, was not "a political move."

Still, Plouffe acknowledged that Obama's team expects an extraordinarily close election. "It's going to come down to a few votes per precinct in a few states," Plouffe said in an interview on NBC's Meet the Press. His comment underscores the reality that a small number of extra votes from Hispanics could make the difference in some key states like Nevada and Colorado.

Obama's order has put Romney in a difficult position, forcing him to decide between possibly alienating Hispanic voters with tough talk or stoking anger within a conservative GOP base that was slow to warm to him during the primary process.

Romney's comments represent a further softening of his rhetoric on immigration since the GOP primary campaign ended.

For example, before the Iowa caucuses in January, when he faced the challenge of winning over the right-wing base of the GOP, he pledged to veto legislation backed by Democrats that would have created a path to citizenship for illegal immigrants brought to the U.S. as children. Instead of emphasizing the plight of illegal immigrants, Romney focused on the consequences illegal immigration has for U.S. jobs.

Obama's immigration announcement disrupted the start of Romney's five-day bus tour through small cities and towns in six important states.

The tour, now on its third day, scheduled three stops, including two in Ohio towns just outside the metropolitan areas of Cleveland and Columbus. Romney spent the first two days in New Hampshire and Pennsylvania, where he assailed Obama and insisted that he's the candidate who will give middle-class Americans "a fair shot."

The Obama administration said the policy change announced Friday will affect as many as 800,000 immigrants who have lived in fear of deportation. Obama's move bypasses Congress and partially achieves the goals of the Democrats' long-stalled legislation aimed at young illegal immigrants who went to college or served in the military.

Romney's CBS interview was his first in more than a year with a Sunday talk show on a network other than Fox. It covered a range of topics, including health care, Romney's political future and the European financial crisis.

Romney said that the American banking sector "is able to weather the storm" in Europe. He said European countries are capable of dealing with their mess "if they choose to do so" and the U.S. doesn't want to get into the business of bailing out foreign banks. Romney also does not favor another round of economic stimulus by the Federal Reserve, saying a previous one didn't have the desired effect.

Romney also taped an interview with C-SPAN, aired Sunday, and emphasized he wouldn't implement an austerity plan in the U.S. if elected. "What we would never do would be to dramatically slash spending by a trillion or $2 trillion as I came into the White House," he said. Instead, Romney said he will cut programs that would have otherwise grown more expensive over time.

saul alinsky annapolis trisomy wwe royal rumble leon panetta luck sag awards 2012 nominees

Sunday, June 17, 2012

Wildfire destroys most homes in Colo. history

A Erickson Air Crane firefighting helicopter flys to a pond to refill its tank while fighting the High Park wildfire, west of Fort Collins, Colo., on Friday, June 15, 2012. The wildfire started Saturday and has burned over 50,000 acres. (AP Photo/Ed Andrieski)

A Erickson Air Crane firefighting helicopter flys to a pond to refill its tank while fighting the High Park wildfire, west of Fort Collins, Colo., on Friday, June 15, 2012. The wildfire started Saturday and has burned over 50,000 acres. (AP Photo/Ed Andrieski)

A Erickson Air Crane firefighting helicopter refills its tank in a rancher's pond while fighting the High Park wildfire west of Fort Collins, Colo., on Friday, June 15, 2012. The wildfire started Saturday and has burned over 50,000 acres. (AP Photo/Ed Andrieski)

A thunderhead builds over the High Park wildfire and Fort Collins, Colo., on Friday, June 15, 2012. Rain could assist in fighting the wildfire that started Saturday and has burned over 50,000 acres. (AP Photo/Ed Andrieski)

A sign warns motorist of the closure of Highway 14 through Poudre Canyon as columns of smoke rise in the distance from the High Park wildfire west of Fort Collins, Colo., on Friday, June 15, 2012. The wildfire started Saturday and has burned over 50,000 acres. (AP Photo/Ed Andrieski)

(AP) ? Crews in northern Colorado braced for powerful fire-fanning winds Saturday as they battle a blaze that has scorched about 85 square miles of mountainous forest land and destroyed at least 181 homes, the most in state history.

The destructiveness of the High Park Fire burning 15 miles west of Fort Collins surpassed the Fourmile Canyon wildfire, which destroyed 169 homes west of Boulder in September 2010.

More than 1,630 personnel worked on the fire Saturday, officials said in a late-night news release. The figure represents an increase of more than 100 firefighters from a day earlier.

The lightning-caused blaze, which is believed to have killed a 62-year-old woman whose body was found in her cabin, was 20 percent contained. The fire's incident commander said full containment could be two to four weeks away.

Fire information officer Brett Haberstick said crews have made progress in containing a 200-acre spot fire that erupted Thursday afternoon north of the Cache La Poudre River, a critical line of defense against northward growth.

"Two 20-person hotshot crews worked throughout the day to secure lines around the perimeter of this spot fire," the officials said in a release.

Firefighters have extinguished other incursions north of the river, but the most recent one appeared to be more serious.

National Weather Service meteorologist Kyle Fredin said some rain was expected in the fire zone Saturday evening, but it will not be enough to put the fire out.

"We need a rain that will really last all day," he said. "But it's better than dry wind at this point."

Crews faced difficult conditions Sunday with wind gusts expected to hit 50 mph along ridge tops and in Poudre Canyon and temperatures in the 90-degree range.

The fire was reported June 9 and has since raced through large swaths of private and U.S. Forest Service land. It was 45 percent contained late Saturday.

Agriculture Secretary Tom Vilsack, who oversees the Forest Service, met with fire managers in Fort Collins on Saturday and said "fighting this fire is going to require us to be aggressive, persistent and also patient.

"We're going to continue to work to make our forests more resilient. We're going to continue to ensure that adequate resources are provided for fighting fires and we are going to continue to make sure that we encourage appropriate stewardship of our forests," he said.

Vilsack praised Congress for allowing the government to contract additional aircraft ? particularly heavy tankers ? to fight wildfires across the West. But he called on lawmakers for budget certainty to help plan for future fires.

Vilsack is scheduled to hold a news conference with U.S. Forest Service Chief Tom Tidwell in Albuquerque on Sunday.

Meanwhile in New Mexico, questions were being raised about whether bureaucratic red tape prevented firefighters from saving more homes affected by the Little Bear Fire after federal officials released transcripts of the firefighters' response.

Congressman Steve Pearce said Friday in an interview with KOB-TV (http://bit.ly/Mga1yx ) that he believed federal officials could have done more after lightning sparked the fire outside the resort town of Ruidoso on June 4. Days later, high winds sent embers more than a mile from the blaze's end, causing the inferno to grow.

But officials released transcripts of the response on the Lincoln National Forest website that suggested firefighters were attacking the blaze as soon as it was a quarter of an acre.

The fire has destroyed 242 homes and commercial structures. It had burned 59 square miles and was 60 percent contained as of Saturday night.

Parts of the area received up to three-quarters of an inch of rain Saturday, aiding the firefight but causing flash flood warnings as a result of burned over forest. Lincoln County Emergency Services ordered an evacuation for residents in low-lying areas and around creeks or streams, but they were allowed to return home in the evening.

In Arizona, a blaze in the Tonto National Forest that doubled in size to 3,100 acres. Officials said Saturday night that the fire was 15 percent contained and firefighters continued to battle unseasonably dry fuels, high temperatures and low humidity.

On Friday, a crew member broke his leg fighting the blaze, which was burning in a remote, mountainous area about 70 miles northeast of Phoenix.

___

Associated Press writer Russell Contreras in Albuquerque contributed to this report.

Associated Press

nfl 2012 schedule gmail down tim lincecum ryan oneal file taxes online tupac shakur sledge hammer

KCIce the Best Supergroup Since the Traveling WIlburys

Stick-tap to pucKChaser for uncovering the mystery of the ice rink in the Northland. ?It will be managed by a group named KCIce, run by 1980 USA Hockey team member and former KC Blades coach Ken Morrow and NHL21's Paul McGannon.

KCIce's official site

Continue after the jump for the full press release on KC Ice and the new Northland rink.

Press Release Via

* * *

New outdoor Rink to Support Ice Based Sports and

Russell Stover Hockey

?Kansas City, MO, June 14, 2012:??KCIce Management Group announced the development of the new outdoor ice rink at The Village of Burlington Creek.??The rink will help support and grow ice based sports, competition and activities in Kansas City, such as the nationally recognized Tier 1 United States travel hockey program, Russell Stover Hockey.??KCIce, a grass roots organization established by a local group of private and public representatives, work towards promoting and growing ice based sports and the recreational activities generated from new ice facilities.??Ken Morrow, President of KCIce, is a member of the 1980 US Olympic ?Miracle on Ice? team and 4-Time Stanley Cup Champion who continually shows his passion for the sport through various outreach programs.???Our mission is to promote and grow ice based sports,? said Morrow.???With the addition of the new outdoor rink in The Village of Burlington Creek, we provide a vehicle, generating revenue, to help support Russell Stover Hockey while offering all families an opportunity to experience the joy of ice skating.??

Russell Stover Hockey is dedicated to the growth and development of top young athletes in the Midwest and across the country.??Russell Stover Hockey provides a challenging environment in which players evolve into well-rounded young men focused on athletic and academic excellence with a commitment to community.

The new rink is the result of a collaborative effort between KCIce and NorthPoint Development.??Paul McGannon, Vice President of KCIce and founder of NHL21, Inc., has a long-standing reputation within the hockey community cultivating Kansas City for the National Hockey League.???The earlier we get kids interested in skating the greater the opportunity to introduce them to hockey,? said McGannon.?

Kansas City has a growing and evolving ice skating community, but a shortage of ice facilities.??This rink is the first of many facilities to go up in the Kansas City area to further promote ice skating.???A new outdoor rink can be a fantastic opportunity to introduce future figure skaters and hockey players to the ice,? added McGannon.???But it?s also about bringing family and the community together.?

NorthPoint Development recently acquired the former Tuileries Plaza earlier this year and is active in reviving the area with more retail stores, restaurants and other attractions.???We hear only enthusiasm and anticipation whenever we discuss the rink with area businesses and the community?, Nathaniel Hagedorn, President and CEO of NorthPoint Development.??The new rink will have seating around fire pits and provide a cozy environment for spectators and shoppers alike.??During the skating season, November thru February, the rink will provide exciting programs and work with schools, companies and organizations for special events.

The collaboration of the groups will deliver Kansas City?s first outdoor rink in the Northland, located in the heart of The Village of Burlington Creek.??The grand opening is anticipated for November 15, 2012.

?* * *


As always, stick close to all KC hockey blog sites for information, especially those with much more journalistic integrity than this one.

stuffing recipe happy thanksgiving kennedy assassination kennedy assassination jfk assassination pie crust recipe heritage foundation

Braves place Beachy on DL, make plans for Jurrjens

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

eli whitney blake griffin dunk on kendrick perkins kendrick perkins steve jones emily maynard kola boof burmese python

Saturday, June 16, 2012

At least 11 killed in second Baghdad blast: sources

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

apple dividend snow white and the huntsman snow white and the huntsman peyton manning rupaul drag race walking dead comic kratom

Cancer's next magic bullet may be magic shotgun

Cancer's next magic bullet may be magic shotgun [ Back to EurekAlert! ] Public release date: 15-Jun-2012
[ | E-mail | Share Share ]

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco

Network approach to drug design may yield more effective and less toxic cancer drugs, UCSF study suggests

A new approach to drug design, pioneered by a group of researchers at the University of California, San Francisco (UCSF) and Mt. Sinai, New York, promises to help identify future drugs to fight cancer and other diseases that will be more effective and have fewer side effects.

Rather than seeking to find magic bulletschemicals that specifically attack one gene or protein involved in one particular part of a disease processthe new approach looks to find "magic shotguns" by sifting through the known universe of chemicals to find the few special molecules that broadly disrupt the whole diseases process.

"We've always been looking for magic bullets," said Kevan Shokat, PhD, a Howard Hughes Medical Institute Investigator and the Chair of the Department of Cellular and Molecular Pharmacology at UCSF. "This is a magic shotgunit doesn't inhibit one target but a set of targetsand that gives us a much, much better ability to stop the cancer without causing as many side effects."

Described in the June 7, 2012 issue of the journal Nature, the magic shotgun approach has already yielded two potential drugs, called AD80 and AD81, which in fruit flies were more effective and less toxic than the drug vandetanib, which was approved by the U.S. Food & Drug Administration last year for the treatment of a certain type of thyroid cancer.

Expanding the Targets to Lower a Drug's Toxicity

Drug design is basically all about disruption. In any disease, there are numerous molecular interactions and other processes that take place within specific tissues, and in the broadest sense, most drugs are simply chemicals that interfere with the proteins and genes involved in those processes. The better a drug disrupts key parts of a disease process, the more effective it is.

The toxicity of a drug, on the other hand, refers to how it also disrupts other parts of the body's system. Drugs always fall short of perfection in this sense, and all pharmaceuticals have some level of toxicity due to unwanted interactions the drugs have with other molecules in the body.

Scientists use something called the therapeutic index (the ratio of effective dose to toxic dose) as a way of defining how severe the side effects of a given drug would be. Many of the safest drugs on the market have therapeutic indexes that are 20 or highermeaning that you would have to take 20 times the prescribed dose to suffer severe side effects.

Many cancer drugs, on the other hand, have a therapeutic index of 1. In other words, the amount of the drug you need to take to treat the cancer is the exact amount that causes severe side effects. The problem, said Shokat, comes down to the fact that cancer drug targets are so similar to normal human proteins that the drugs have widespread effects felt far outside the tumor.

While suffering the side effects of drugs is a reality that many people with cancer bravely face, finding ways of minimizing this toxicity is a big goal pharmaceutical companies would like to solve. Shokat and his colleagues believe the shotgun approach is one way to do this.

The dogma that the best drugs are the most selective could be wrong, he said, and for cancer a magic shotgun may be more effective than a magic bullet.

Looking at fruit flies, they found a way to screen compounds to find the few that best disrupt an entire network of interacting genes and proteins. Rather than judging a compound according to how well it inhibits a specific target, they judged as best the compounds that inhibited not only that specific target but disrupted other parts of the network while not interacting with other genes and proteins that would cause toxic side effects.

###

The article, "Chemical genetic discovery of targets and anti-targets for cancer polypharmacology" by Arvin C. Dar, Tirtha K. Das, Kevan M. Shokat and Ross Cagan appears in the June 7, 2012 issue of the journal Nature. See: http://dx.doi.org/10.1038/nature11127

This work was supported by the American Cancer Society, The Waxman Foundation, and the National Institutes of Healththrough grants R01CA109730, R01CA084309, R01EB001987 and P01 CA081403-11.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

Follow UCSF

UCSF.edu | Facebook.com/ucsf | Twitter.com/ucsf | YouTube.com/ucsf



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Cancer's next magic bullet may be magic shotgun [ Back to EurekAlert! ] Public release date: 15-Jun-2012
[ | E-mail | Share Share ]

Contact: Jason Socrates Bardi
jason.bardi@ucsf.edu
415-502-6397
University of California - San Francisco

Network approach to drug design may yield more effective and less toxic cancer drugs, UCSF study suggests

A new approach to drug design, pioneered by a group of researchers at the University of California, San Francisco (UCSF) and Mt. Sinai, New York, promises to help identify future drugs to fight cancer and other diseases that will be more effective and have fewer side effects.

Rather than seeking to find magic bulletschemicals that specifically attack one gene or protein involved in one particular part of a disease processthe new approach looks to find "magic shotguns" by sifting through the known universe of chemicals to find the few special molecules that broadly disrupt the whole diseases process.

"We've always been looking for magic bullets," said Kevan Shokat, PhD, a Howard Hughes Medical Institute Investigator and the Chair of the Department of Cellular and Molecular Pharmacology at UCSF. "This is a magic shotgunit doesn't inhibit one target but a set of targetsand that gives us a much, much better ability to stop the cancer without causing as many side effects."

Described in the June 7, 2012 issue of the journal Nature, the magic shotgun approach has already yielded two potential drugs, called AD80 and AD81, which in fruit flies were more effective and less toxic than the drug vandetanib, which was approved by the U.S. Food & Drug Administration last year for the treatment of a certain type of thyroid cancer.

Expanding the Targets to Lower a Drug's Toxicity

Drug design is basically all about disruption. In any disease, there are numerous molecular interactions and other processes that take place within specific tissues, and in the broadest sense, most drugs are simply chemicals that interfere with the proteins and genes involved in those processes. The better a drug disrupts key parts of a disease process, the more effective it is.

The toxicity of a drug, on the other hand, refers to how it also disrupts other parts of the body's system. Drugs always fall short of perfection in this sense, and all pharmaceuticals have some level of toxicity due to unwanted interactions the drugs have with other molecules in the body.

Scientists use something called the therapeutic index (the ratio of effective dose to toxic dose) as a way of defining how severe the side effects of a given drug would be. Many of the safest drugs on the market have therapeutic indexes that are 20 or highermeaning that you would have to take 20 times the prescribed dose to suffer severe side effects.

Many cancer drugs, on the other hand, have a therapeutic index of 1. In other words, the amount of the drug you need to take to treat the cancer is the exact amount that causes severe side effects. The problem, said Shokat, comes down to the fact that cancer drug targets are so similar to normal human proteins that the drugs have widespread effects felt far outside the tumor.

While suffering the side effects of drugs is a reality that many people with cancer bravely face, finding ways of minimizing this toxicity is a big goal pharmaceutical companies would like to solve. Shokat and his colleagues believe the shotgun approach is one way to do this.

The dogma that the best drugs are the most selective could be wrong, he said, and for cancer a magic shotgun may be more effective than a magic bullet.

Looking at fruit flies, they found a way to screen compounds to find the few that best disrupt an entire network of interacting genes and proteins. Rather than judging a compound according to how well it inhibits a specific target, they judged as best the compounds that inhibited not only that specific target but disrupted other parts of the network while not interacting with other genes and proteins that would cause toxic side effects.

###

The article, "Chemical genetic discovery of targets and anti-targets for cancer polypharmacology" by Arvin C. Dar, Tirtha K. Das, Kevan M. Shokat and Ross Cagan appears in the June 7, 2012 issue of the journal Nature. See: http://dx.doi.org/10.1038/nature11127

This work was supported by the American Cancer Society, The Waxman Foundation, and the National Institutes of Healththrough grants R01CA109730, R01CA084309, R01EB001987 and P01 CA081403-11.

UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.

Follow UCSF

UCSF.edu | Facebook.com/ucsf | Twitter.com/ucsf | YouTube.com/ucsf



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


ann coulter tom brady sister dad shoots daughters laptop brandon jennings channing tatum the vow review luol deng

Liu Yang draws cheers as first Chinese woman set for space voyage

JIUQUAN, China | Fri Jun 15, 2012 8:21am EDT

JIUQUAN, China (Reuters) - China will send its first woman into outer space this week, prompting a surge of national pride as the rising power takes its latest step towards putting a space station in orbit within the decade.

Liu Yang, a 33-year-old fighter pilot, will join two other astronauts aboard the Shenzhou 9 spacecraft when it lifts off from a remote Gobi Desert launch site on Saturday evening.

They will attempt a manned docking for the first time with the Tiangong (Heavenly Palace) 1 module, launched last September and part of China's exploratory preparations for a space lab.

Rendezvous and docking exercises between the two vessels will be an important hurdle in China's efforts to acquire the technological and logistical skills needed to run a full space lab that can house astronauts for long stretches.

Beijing is still far from catching up with the established space superpowers: the United States and Russia. The Tiangong 1 is a trial module, not the building block of a space station.

But the docking mission will be the latest show of China's growing prowess in space, alongside its growing military and diplomatic presence, and comes while budget restraints and shifting priorities have held back U.S. manned space launches.

Speaking to the official Xinhua news agency, Liu said she "yearns to experience the wondrous, weightless environment of space, see the Earth and gaze upon the motherland".

"Thank you for the confidence put in my by the motherland and the people, for giving me this chance to represent China's millions of women by going into space," Liu later told reporters at the Jiuquan launch center.

Medical experts who helped select the crew of the Shenzhou 9, have said that female astronauts must meet the same criteria as men, and then some, according to the China Daily.

Female Chinese astronauts must be married and preferably be mothers, the newspaper said, citing concerns that radiation would "harm their fertility".

Liu, from the poor and populous central province of Henan, has been praised in state media for her nerves of steel after safely landing her fighter jet after a bird strike that left the cockpit glass covered with blood.

China's latest space mission has attracted even more than the usual national attention thanks to Liu's presence.

Her selection to the mission team rapidly became the top subject on the country's Twitter-like microblogging service Sina Weibo, with 33 million posts.

"Liu Yang, on the eve of becoming our first woman is space, is the pride of Henan," wrote one user.

But others wondered if the money poured into space ambitions would be better used on Earth, where China is still a developing country and grappling with more mundane issues like food safety and a growing rich-poor divide.

"What use does Shenzhou 9 have? Will it help the people to not starve?" another user wrote.

(Additional reporting by Michael Martina, Ben Blanchard and Sabrina Mao in Beijing; Editing by Ron Popeski)

ash wednesday kate walsh cnn debate equatorial guinea marine helicopter crash chicago weather star jones

Economy: Canada needs to boost innovation and human capital to sustain living standards



13/06/12 - Canada has weathered the global economic crisis comparatively well but will have to become more productive to sustain its high standard of living, according to OECD?s latest?Economic Survey of Canada.


The report, presented today in Ottawa, notes that a timely fiscal stimulus, low interest rates, a solid banking sector and revenues from natural resources helped Canada? return to a stable growth path after the global economic crisis of 2008-09. With rising real estate prices and high household indebtedness now posing new risks, the OECD projects that Canada?s economy will grow by around 2? per cent in 2012, and by around 2? per cent in 2013.


The report identifies sluggish productivity growth as the main long-term challenge facing Canada?s economy. Per capita income has increased in recent years, as more people entered the labour force and oil and other commodity prices soared, pushing up the value of the Canadian dollar. However, the amount of labour, capital and natural resources needed to produce a unit of GDP has remained largely the same over the past few decades.


Canada?s overall productivity has actually fallen since 2002, while it has grown by about 30% over the past 20 years in the United States. At the same time, income has shifted towards the resource-rich western provinces, while the regional economies of Ontario and Quebec are still adapting to increased external competition resulting from the high exchange rate.


?Canada is blessed with abundant natural resources. But it needs to do more to develop other sectors of the economy if it is to maintain a high level of employment and an equitable distribution of the fruits of growth,? said Peter Jarrett, one of the authors of the study and the head of the Canada division at the OECD Economics Department.


The OECD identifies two key priorities for meeting this long-term challenge. First, Canada needs to boost innovation. Canada has world-class research institutions and provides strong public support to business investment in research and development (R&D). However, the business sector devotes only about 1% of GDP to R&D, compared with 2% in the U.S. and more than 2.5% in Japan, Korea and some of the Nordic countries. Canada remains a low performer on business investment in R&D, even when the large share of natural resource production is taken into account.


The OECD recommends more focused support for business investment in R&D. The government should maintain the current system of tax credits; however, particularly generous credits to small Canadian-owned private firms should be reined in and partly replaced by more targeted direct grants. Opening up network industries and liberal professions to more competition would also enhance incentives for innovation, thereby generating higher productivity.


Second, Canada should invest further to improve both quality and access to tertiary education, to maintain the supply of highly skilled workers as the population ages. Financial assistance to students should become more targeted and granted on a means-tested basis. This would help reduce the barriers for financially disadvantaged students and promote more socially inclusive growth.


Tertiary education should also become more flexible and facilitate lifelong learning. Canada should seek to attract more foreign students into its tertiary system and make it easier for them to work and stay in Canada after graduation. Finally, the report suggests that universities be differentiated between institutions that engage in research and those that focus primarily on teaching.


Further information on the Economic Survey of Canada is available at: www.oecd.org/eco/surveys/canada.

?

For more information journalists are invited to contact?Matthias Rumpf at the OECD Weshington Centre on +1 (202) 445 80 58

matt lauer divine mercy chaplet albert pujols the shining mariano rivera mariano rivera jobs report

Friday, June 15, 2012

Tinnitus Sufferers Hoping Serenade Sound Therapy Can Relieve Ear Ringing

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

yamaguchi road house occupy oakland occupy oakland morgellons disease arik armstead sag awards red carpet

WTC workers gear up for Obama visit (CNN)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

vanna white michael robinson joe paterno memorial service taco bell breakfast menu ener1 national chocolate cake day epstein